COVID-flu combination vaccine shows positive results in late-stage trial, Moderna says
There could be a combined COVID-19 and flu shot in our future, although it won바카라 게임 웹사이트t be ready for this year바카라 게임 웹사이트s flu season.
On Monday, vaccine maker Moderna positive late-stage trial results for its COVID-flu combination vaccine it calls mRNA-1083.
Calling the outcome of the late-stage trial 바카라 게임 웹사이트breakthrough results,바카라 게임 웹사이트 Moderna바카라 게임 웹사이트s Chief Medical Affairs Officer Francesca Ceddia told CNN that people in the trial who got mRNA-1083 showed an improved immune response compared with those who got the standalone flu and COVID vaccines that are available now. The results were true even for people in the trial who were 65 years and older. Generally, older people don바카라 게임 웹사이트t mount as robust a response to vaccines as younger people do.
바카라 게임 웹사이트When we think about the combination vaccine, we often only think about the element of convenience, one shot instead of two, but what is really, really breakthrough is the fact that you not only offer that advantage, you also offer the proof of clinical benefit. I think this is the most important message,바카라 게임 웹사이트 Ceddia said.
Other companies a combined COVID-flu vaccine, but Moderna is the first to announce positive late-stage trial results.
Public health leaders say the world could use more ways to protect people from both viruses. Millions of people get sick with the flu and now COVID every year. For the last flu season, the estimates 35 to 64 million people got sick with the flu in the United States. Between 390,000 and 810,000 people were so sick they were hospitalized and up to 71,000 people died. Just for last fall and winter, COVID sent more than a half-million people in the U.S. to the hospital and killed 40,000, according to data presented last week to the Food and Drug Administration바카라 게임 웹사이트s independent vaccine advisers, who were discussing how to update COVID vaccines for the fall.
Moderna바카라 게임 웹사이트s Phase 3 trial was a randomized, observer-blind, active control study, meaning that even the clinicians giving the shots didn바카라 게임 웹사이트t know who got which vaccines. The trial studied the vaccine in two different age groups with about 4,000 adults in each age category.
For one part of the study, Moderna compared the immune reaction of adults 65 and older who got mRNA-1083 and another group with the same age range who got a co-administered COVID-19 vaccine, Moderna바카라 게임 웹사이트s Spikevax, and an enhanced flu vaccine, Fluzone HD. seniors get more powerful flu vaccines due to their inhibited immune systems.
For the other part of the trial, researchers compared how slightly younger adults, ages 50 to 64, did when they got the mRNA-1083 vaccine to another group within the same age range who got Spikevax and a standard dose flu vaccine called Fluarix.
Study results showed that in both age groups, the experimental combination vaccine elicited a statistically significant higher immune response against three strains of the flu and against COVID-19, compared with the co-administered shots.
바카라 게임 웹사이트The titers are significantly higher,바카라 게임 웹사이트 Ceddia said. 바카라 게임 웹사이트This is better actually.바카라 게임 웹사이트 A titer is a lab test that measures the number of antibodies in the blood and it can be used to prove how immune someone is to the disease.
In terms of safety, the combined vaccine was well-tolerated, Moderna said, and the adverse reactions were similar to what people experienced with the co-administered vaccines. The most common complaints were pain at the injection site, tiredness, muscle pain and headaches.
The study isn바카라 게임 웹사이트t peer-reviewed yet, but Moderna said it plans to present data from this late-stage trial at an upcoming medical conference and it will also submit the trial for publication. Moderna also said it will talk to the FDA about possible next steps.
바카라 게임 웹사이트We need to engage with regulators but our aspiration is to have it approved for fall 2025,바카라 게임 웹사이트 Moderna CEO Stéphane Bancel told CNN.
Sue Peschin, the president and CEO of the Alliance for Aging Research, a nonprofit dedicated to improving aging and health that encourages more equitable access to vaccines, said a combined shot could be a significant help to public health.
In addition to intensifying vaccine hesitancy in the U.S., people have developed a kind of vaccine fatigue after the pandemic, Peschin said. Peschin pointed to the drop in the uptake in standard vaccines vaccine, as well as in seasonal vaccines.
Few people got the latest COVID shot, studies show. Only about 25% of the eligible population has received the latest COVID-19 vaccine, according to a presentation to the FDA last week. Many more adults got the flu shot with nearly half of the adult population getting one last season, , a number that was slightly higher than the year before.
바카라 게임 웹사이트We want to see that go up and if there바카라 게임 웹사이트s a way to do that by combining the vaccines, then that바카라 게임 웹사이트s better for everyone because it helps protect everyone in the community,바카라 게임 웹사이트 Peschin said. 바카라 게임 웹사이트We would love to see the combination vaccines come to market if the FDA deems them safe and effective.바카라 게임 웹사이트
CNN바카라 게임 웹사이트s Meg Tirrell contributed to this report.