Catera Bentley stared at the positive pregnancy test and couldn바카라 게임 웹사이트t believe her eyes. She took a second test, then a third 바카라 게임 웹사이트 there was no question. She was pregnant.She called her husband at work and told him that there was a giant spider in the house that he had to come get rid of. He rushed home, and when he arrived, Bentley revealed the news. They both burst into tears.The couple, who live in Steele, Alabama, had been trying to have a child for more than two years, but Bentley바카라 게임 웹사이트s doctor had told her that she may be unable to conceive because of her history of polycystic ovary syndrome, known as PCOS.The news had left her feeling without a purpose. 바카라 게임 웹사이트That바카라 게임 웹사이트s all I wanted to be was a mom and a wife,바카라 게임 웹사이트 said Bentley, 25. 바카라 게임 웹사이트I was depressed, severely depressed for that whole time.바카라 게임 웹사이트Five months earlier, in October 2022, Bentley had started taking Mounjaro for weight loss. Over the first few months, she said, she lost about 40 pounds. Her menstrual cycles, which had been irregular because of PCOS, became normal. And she even felt happier.바카라 게임 웹사이트It just made me feel like a whole new person,바카라 게임 웹사이트 she said. 바카라 게임 웹사이트I was in a better mood every single day.바카라 게임 웹사이트Bentley had hoped that losing weight might help her get pregnant, and she바카라 게임 웹사이트d heard about others having success with weight loss while taking the shot. But when she did become pregnant 바카라 게임 웹사이트 sooner than she expected 바카라 게임 웹사이트 she worried about the effects it might have on her baby.'Ozempic babies'Bentley is far from alone. Numerous women have shared stories of 바카라 게임 웹사이트Ozempic babies바카라 게임 웹사이트 on social media. But the joy some experience in discovering pregnancies may come with anxiety about the unknowns, as these medicines haven바카라 게임 웹사이트t been studied in people who are pregnant. 바카라 게임 웹사이트We don바카라 게임 웹사이트t know the effect of early exposure 바카라 게임 웹사이트 on the fetus,바카라 게임 웹사이트 said Dr. Jody Dushay, a physician focused on endocrinology and metabolism at Beth Israel Deaconess Medical Center and an assistant professor at Harvard Medical School.Dushay said she recommends that women stop taking these drugs two months before trying to get pregnant, as directed in their prescribing information.Ozempic and Mounjaro are part of a class of drugs called GLP-1 receptor agonists, which act by mimicking hormones in the gut involved in insulin regulation and appetite. They바카라 게임 웹사이트re both approved to treat type 2 diabetes, and each have twin medicines approved for weight loss. Ozempic uses the active ingredient semaglutide, and Wegovy is the version approved for weight loss. Mounjaro uses tirzepatide, which also targets a second hormone called GIP, and Zepbound is its brand name for weight loss.The medicines have been shown to help people lose 15% to 20% of their body weight, on average, in clinical trials.And because of the way GLP-1 drugs work, experts say, there are reasons they may lead to more pregnancies as well as cause for caution about their use in early pregnancy.An effect on birth controlFor one, weight loss can generally be associated with increased fertility by restoring normal ovulation in people who have PCOS or other causes of abnormal cycles, said Dr. Daniel Drucker, a professor and researcher at the University of Toronto바카라 게임 웹사이트s Mount Sinai Hospital and a pioneer of research into GLP-1.바카라 게임 웹사이트If you start on these medicines and then you lose 5, 10, 15% of your body weight, very often, you will have an improvement in ovulation,바카라 게임 웹사이트 Drucker said.One scenario that바카라 게임 웹사이트s 바카라 게임 웹사이트quite conceivable,바카라 게임 웹사이트 he said, is that someone who has obesity and doesn바카라 게임 웹사이트t have frequent menstrual periods starts one of these medicines, loses weight over several months and finds that they바카라 게임 웹사이트re still not having regular periods 바카라 게임 웹사이트 바카라 게임 웹사이트only now it might be because you바카라 게임 웹사이트re pregnant.바카라 게임 웹사이트Video below: High cost makes weight loss, diabetes drugs inaccessibleOn top of that, Mounjaro and Zepbound have a warning in their prescribing information that they may render birth control pills less effective.Drucker said this may be because the drugs work in part by slowing the rate at which food moves through the stomach. This can make people feel full for longer but also could interfere with absorption of other medicines, including birth control pills.Mounjaro and Zepbound warn about this explicitly on their labels, but Ozempic and Wegovy only warn more broadly about absorption of any drugs taken by mouth.Safety in pregnancyEven as GLP-1 medicines may increase fertility, little is known about their safety during pregnancy. The drugs바카라 게임 웹사이트 makers, Novo Nordisk and Eli Lilly, excluded people who were pregnant or planned to become pregnant from their clinical trials, a common practice when testing new medicines.But that doesn바카라 게임 웹사이트t mean there바카라 게임 웹사이트s no information available.바카라 게임 웹사이트The more these meds are used, the more women will get pregnant while taking them, and we will in that way accumulate data on risk of early pregnancy exposure,바카라 게임 웹사이트 Dushay explained. In other words, 바카라 게임 웹사이트we basically gather data from 바카라 게임 웹사이트accidents바카라 게임 웹사이트 as we do for most drugs.바카라 게임 웹사이트The few studies available about babies whose mothers took GLP-1s early in pregnancy haven바카라 게임 웹사이트t turned up major causes for concern, although researchers note that more study is needed 바카라 게임 웹사이트 and it바카라 게임 웹사이트s underway.Novo Nordisk has a registry where it바카라 게임 웹사이트s collecting data about the safety of Wegovy during pregnancy. A company spokesperson says the findings will be disclosed at the end of the study. An entry on a government database on clinical trials notes that the study plans to enroll more than 1,100 participants and is expected to be completed by the summer of 2027.An Eli Lilly spokesperson said the company also plans to open a pregnancy registry for Zepbound, which was approved at the end of last year.Studies in animals, though, have suggested some cause for caution, Drucker said.바카라 게임 웹사이트If animals get high doses of these drugs, very often, the babies that are born to the mice and rats are small, and sometimes, they have some malformations,바카라 게임 웹사이트 he noted.That바카라 게임 웹사이트s probably because the drugs also work by reducing appetite.바카라 게임 웹사이트If you restrict energy intake in a pregnant animal, then the baby바카라 게임 웹사이트s not going to get enough nutrients and won바카라 게임 웹사이트t be able to grow properly,바카라 게임 웹사이트 Drucker said.He also pointed to a study in animals suggesting that GLP-1 drugs may reduce the number of proteins that are responsible for transferring nutrients from the mother to the fetus, often found in the placenta.Already in use for PCOSThose concerns complicate research on the medicines for infertility, but some work is ongoing on one of the most common causes: PCOS. The condition affects as many as 12% of women of reproductive age in the United States, according to the U.S. Centers for Disease Control and Prevention.The exact cause of PCOS is unknown, but it바카라 게임 웹사이트s associated with excess weight, which is thought to contribute to the body바카라 게임 웹사이트s production of too much insulin. That, in turn, results in hormonal imbalances 바카라 게임 웹사이트 specifically, higher levels of hormones like testosterone, which can stop ovulation and cause irregular periods, acne and excess facial hair, according to the CDC.Although there바카라 게임 웹사이트s no cure, weight loss alone can lead to significant improvement of symptoms and resumption of regular ovulation and menstruation, said Dr. Anuja Dokras, director of the PCOS clinic at the University of Pennsylvania.Lifestyle changes are the first-line treatment for PCOS, but if those interventions aren바카라 게임 웹사이트t successful, doctors may prescribe Ozempic or other GLP-1 agonist medications, Dokras said. The 2023 international PCOS guidelines list GLP-1 agonists among the medications for 바카라 게임 웹사이트management of higher weight in adults with PCOS.바카라 게임 웹사이트GLP-1 agonists improve insulin resistance and lead to weight loss, so it makes sense that they also improve PCOS symptoms, added Dr. Melanie Cree, director of the multidisciplinary PCOS Clinic at Children바카라 게임 웹사이트s Hospital Colorado.바카라 게임 웹사이트It is completely being used now with no evidence because the field knows that if you have 5% weight loss in these individuals with PCOS, you will improve fertility,바카라 게임 웹사이트 she said.Cree noted that studies have shown that liraglutide, an earlier GLP-1 drug sold as Victoza for type 2 diabetes and Saxenda for weight loss, is effective at reducing body weight and testosterone levels in women with PCOS and obesity.Cree also just wrapped up a clinical trial investigating the use of semaglutide, the active ingredient in Ozempic and Wegovy, for PCOS treatment in adolescent girls. The preliminary findings, which have not been published, showed that both semaglutide and a low-sugar diet resulted in more frequent periods, lower testosterone levels and weight loss 바카라 게임 웹사이트 and the weight loss was much more pronounced in the group taking semaglutide.Regardless of the method, the study found, people who lost more weight had greater decreases in testosterone levels.Cree is now running a larger and longer clinical trial, funded by the National Institutes of Health, that will look specifically at fertility outcomes for young women with PCOS who take semaglutide.And while the drugs바카라 게임 웹사이트 makers aren바카라 게임 웹사이트t currently running trials in PCOS 바카라 게임 웹사이트 which Cree attributes in part to the fact that PCOS overlaps so much with obesity that it wouldn바카라 게임 웹사이트t dramatically expand the market for the medicines 바카라 게임 웹사이트 approval for the condition, she pointed out, could have an important effect on insurance coverage, which is challenging for many people using them for weight loss.바카라 게임 웹사이트For example, Colorado mandates fertility coverage, so if it was approved as a fertility medication, then it would be covered for that indication,바카라 게임 웹사이트 she said.Separately, Cree pointed to another question about the medicines during pregnancy: the potential for quick weight regain that can happen when patients stop them suddenly.바카라 게임 웹사이트If that바카라 게임 웹사이트s happening in the setting of pregnancy, when you바카라 게임 웹사이트re gaining all this weight, what happens?바카라 게임 웹사이트 she said. 바카라 게임 웹사이트What does that mean? And we just don바카라 게임 웹사이트t know.바카라 게임 웹사이트A 바카라 게임 웹사이트Catch-22바카라 게임 웹사이트The drugs바카라 게임 웹사이트 makers are also following the 바카라 게임 웹사이트Ozempic babies바카라 게임 웹사이트 phenomenon. Eli Lilly바카라 게임 웹사이트s chief of research, Dr. Daniel Skovronsky, says the company has heard these kinds of stories from patients.바카라 게임 웹사이트One question we바카라 게임 웹사이트re asking is: is it possible that as we reduce fat, we improve fertility, decrease PCOS and other barriers to fertility?바카라 게임 웹사이트 Skovronsky said.바카라 게임 웹사이트It바카라 게임 웹사이트s kind of like heart failure or sleep apnea,바카라 게임 웹사이트 he said, referring to conditions for which GLP-1 drugs have recently shown positive results. 바카라 게임 웹사이트Just another potential benefit of weight loss from this class of medications that we haven바카라 게임 웹사이트t tested yet.바카라 게임 웹사이트He also underlined how tricky it is to run studies around fertility of medicines whose safety in pregnancy is unknown; Cree referred to a requirement for birth control in studies of GLP-1 drugs as a 바카라 게임 웹사이트Catch-22바카라 게임 웹사이트 for fertility indications.바카라 게임 웹사이트Right now, unfortunately, it바카라 게임 웹사이트s really hard to study the effects of these drugs on fertility, because that implies exposing women to a drug with a high risk that they바카라 게임 웹사이트ll have a pregnancy during exposure to the drug and the risks to the baby haven바카라 게임 웹사이트t been fully analyzed yet,바카라 게임 웹사이트 Skovronsky said.Bentley, who got pregnant while taking Mounjaro, said she stopped taking the medicine as soon as she found out she was pregnant. But she said she continued to worry about the effect of the drug on her baby.바카라 게임 웹사이트I worried up until the day I had her,바카라 게임 웹사이트 she said.Her daughter, Ivy, was born healthy on her due date, weighing 7 pounds and 7 ounces. Bentley started taking Mounjaro again six weeks after Ivy was born.
Catera Bentley stared at the positive pregnancy test and couldn바카라 게임 웹사이트t believe her eyes. She took a second test, then a third 바카라 게임 웹사이트 there was no question. She was pregnant.
She called her husband at work and told him that there was a giant spider in the house that he had to come get rid of. He rushed home, and when he arrived, Bentley revealed the news. They both burst into tears.
The couple, who live in Steele, Alabama, had been trying to have a child for more than two years, but Bentley바카라 게임 웹사이트s doctor had told her that she may be unable to conceive because of her history of polycystic ovary syndrome, known as PCOS.
The news had left her feeling without a purpose. 바카라 게임 웹사이트That바카라 게임 웹사이트s all I wanted to be was a mom and a wife,바카라 게임 웹사이트 said Bentley, 25. 바카라 게임 웹사이트I was depressed, severely depressed for that whole time.바카라 게임 웹사이트
Five months earlier, in October 2022, Bentley had started taking Mounjaro for weight loss. Over the first few months, she said, she lost about 40 pounds. Her menstrual cycles, which had been irregular because of PCOS, became normal. And she even felt happier.
바카라 게임 웹사이트It just made me feel like a whole new person,바카라 게임 웹사이트 she said. 바카라 게임 웹사이트I was in a better mood every single day.바카라 게임 웹사이트
Bentley had hoped that losing weight might help her get pregnant, and she바카라 게임 웹사이트d heard about others having success with weight loss while taking the shot. But when she did become pregnant 바카라 게임 웹사이트 sooner than she expected 바카라 게임 웹사이트 she worried about the effects it might have on her baby.
Catera Bentley via CNN 온라인 바카라 게임ource
Catera Bentley and her husband tried for more than two years to have a child. She became pregnant after taking Mounjaro.
'Ozempic babies'
Bentley is far from alone. Numerous women have shared stories of 바카라 게임 웹사이트Ozempic babies바카라 게임 웹사이트 on social media. But the joy some experience in discovering pregnancies may come with anxiety about the unknowns, as these medicines haven바카라 게임 웹사이트t been studied in people who are pregnant.
바카라 게임 웹사이트We don바카라 게임 웹사이트t know the effect of early exposure 바카라 게임 웹사이트 on the fetus,바카라 게임 웹사이트 said Dr. Jody Dushay, a physician focused on endocrinology and metabolism at Beth Israel Deaconess Medical Center and an assistant professor at Harvard Medical School.
Dushay said she recommends that women stop taking these drugs two months before trying to get pregnant, as directed in their prescribing information.
Ozempic and Mounjaro are part of a class of drugs called GLP-1 receptor agonists, which act by mimicking hormones in the gut involved in insulin regulation and appetite. They바카라 게임 웹사이트re both approved to treat type 2 diabetes, and each have twin medicines approved for weight loss. Ozempic uses the active ingredient semaglutide, and Wegovy is the version approved for weight loss. Mounjaro uses tirzepatide, which also targets a second hormone called GIP, and Zepbound is its brand name for weight loss.
The medicines have been shown to help people lose 15% to 20% of their body weight, on average, in clinical trials.
And because of the way GLP-1 drugs work, experts say, there are reasons they may lead to more pregnancies as well as cause for caution about their use in early pregnancy.
An effect on birth control
For one, weight loss can generally be associated with increased fertility by restoring normal ovulation in people who have PCOS or other causes of abnormal cycles, said , a professor and researcher at the University of Toronto바카라 게임 웹사이트s Mount Sinai Hospital and a pioneer of research into GLP-1.
바카라 게임 웹사이트If you start on these medicines and then you lose 5, 10, 15% of your body weight, very often, you will have an improvement in ovulation,바카라 게임 웹사이트 Drucker said.
One scenario that바카라 게임 웹사이트s 바카라 게임 웹사이트quite conceivable,바카라 게임 웹사이트 he said, is that someone who has obesity and doesn바카라 게임 웹사이트t have frequent menstrual periods starts one of these medicines, loses weight over several months and finds that they바카라 게임 웹사이트re still not having regular periods 바카라 게임 웹사이트 바카라 게임 웹사이트only now it might be because you바카라 게임 웹사이트re pregnant.바카라 게임 웹사이트
Video below: High cost makes weight loss, diabetes drugs inaccessible
On top of that, Mounjaro and Zepbound have a warning in their that they may render birth control pills less effective.
Drucker said this may be because the drugs work in part by slowing the rate at which food moves through the stomach. This can make people feel full for longer but also could interfere with absorption of other medicines, including birth control pills.
Mounjaro and Zepbound warn about this explicitly on their labels, but and only warn more broadly about absorption of any drugs taken by mouth.
Safety in pregnancy
Even as GLP-1 medicines may increase fertility, little is known about their safety during pregnancy. The drugs바카라 게임 웹사이트 makers, Novo Nordisk and Eli Lilly, excluded people who were pregnant or planned to become pregnant from their clinical trials, a common practice when testing new medicines.
But that doesn바카라 게임 웹사이트t mean there바카라 게임 웹사이트s no information available.
바카라 게임 웹사이트The more these meds are used, the more women will get pregnant while taking them, and we will in that way accumulate data on risk of early pregnancy exposure,바카라 게임 웹사이트 Dushay explained. In other words, 바카라 게임 웹사이트we basically gather data from 바카라 게임 웹사이트accidents바카라 게임 웹사이트 as we do for most drugs.바카라 게임 웹사이트
The available about babies whose mothers took GLP-1s early in pregnancy haven바카라 게임 웹사이트t turned up major causes for concern, although researchers note that more study is needed 바카라 게임 웹사이트 and it바카라 게임 웹사이트s underway.
Novo Nordisk has a where it바카라 게임 웹사이트s collecting data about the safety of Wegovy during pregnancy. A company spokesperson says the findings will be disclosed at the end of the study. An on a government database on clinical trials notes that the study plans to enroll more than 1,100 participants and is expected to be completed by the summer of 2027.
An Eli Lilly spokesperson said the company also plans to open a pregnancy registry for Zepbound, which was approved at the end of last year.
Studies in animals, though, have suggested some cause for caution, Drucker said.
바카라 게임 웹사이트If animals get high doses of these drugs, very often, the babies that are born to the mice and rats are small, and sometimes, they have some malformations,바카라 게임 웹사이트 he noted.
That바카라 게임 웹사이트s probably because the drugs also work by reducing appetite.
바카라 게임 웹사이트If you restrict energy intake in a pregnant animal, then the baby바카라 게임 웹사이트s not going to get enough nutrients and won바카라 게임 웹사이트t be able to grow properly,바카라 게임 웹사이트 Drucker said.
He also pointed to a study in animals suggesting that GLP-1 drugs may reduce the number of proteins that are responsible for transferring nutrients from the mother to the fetus, often found in the placenta.
Already in use for PCOS
Those concerns complicate research on the medicines for infertility, but some work is ongoing on one of the most common causes: PCOS. The condition affects as many as 12% of women of reproductive age in the United States, according to the .
The exact cause of PCOS is unknown, but it바카라 게임 웹사이트s associated with excess weight, which is thought to contribute to the body바카라 게임 웹사이트s production of too much insulin. That, in turn, results in hormonal imbalances 바카라 게임 웹사이트 specifically, higher levels of hormones like testosterone, which can stop ovulation and cause irregular periods, acne and excess facial hair, according to the .
Although there바카라 게임 웹사이트s no cure, weight loss alone can lead to significant improvement of symptoms and resumption of regular ovulation and menstruation, said , director of the PCOS clinic at the University of Pennsylvania.
Lifestyle changes are the first-line treatment for PCOS, but if those interventions aren바카라 게임 웹사이트t successful, doctors may prescribe Ozempic or other GLP-1 agonist medications, Dokras said. The list GLP-1 agonists among the medications for 바카라 게임 웹사이트management of higher weight in adults with PCOS.바카라 게임 웹사이트
GLP-1 agonists improve insulin resistance and lead to weight loss, so it makes sense that they also improve PCOS symptoms, added , director of the multidisciplinary PCOS Clinic at Children바카라 게임 웹사이트s Hospital Colorado.
바카라 게임 웹사이트It is completely being used now with no evidence because the [obstetrics] field knows that if you have 5% weight loss in these individuals with PCOS, you will improve fertility,바카라 게임 웹사이트 she said.
Cree noted that have shown that , an earlier GLP-1 drug sold as Victoza for type 2 diabetes and Saxenda for weight loss, is effective at reducing body weight and testosterone levels in women with PCOS and obesity.
Cree also just wrapped up a investigating the use of semaglutide, the active ingredient in Ozempic and Wegovy, for PCOS treatment in adolescent girls. The preliminary findings, which have not been published, showed that both semaglutide and a low-sugar diet resulted in more frequent periods, lower testosterone levels and weight loss 바카라 게임 웹사이트 and the weight loss was much more pronounced in the group taking semaglutide.
Regardless of the method, the study found, people who lost more weight had greater decreases in testosterone levels.
Cree is now running a , funded by the National Institutes of Health, that will look specifically at fertility outcomes for young women with PCOS who take semaglutide.
And while the drugs바카라 게임 웹사이트 makers aren바카라 게임 웹사이트t currently running trials in PCOS 바카라 게임 웹사이트 which Cree attributes in part to the fact that PCOS overlaps so much with obesity that it wouldn바카라 게임 웹사이트t dramatically expand the market for the medicines 바카라 게임 웹사이트 approval for the condition, she pointed out, could have an important effect on insurance coverage, which is challenging for many people using them for weight loss.
바카라 게임 웹사이트For example, Colorado mandates fertility coverage, so if it was approved as a fertility medication, then it would be covered for that indication,바카라 게임 웹사이트 she said.
Separately, Cree pointed to another question about the medicines during pregnancy: the potential for quick weight regain that can happen when patients stop them suddenly.
바카라 게임 웹사이트If that바카라 게임 웹사이트s happening in the setting of pregnancy, when you바카라 게임 웹사이트re gaining all this weight, what happens?바카라 게임 웹사이트 she said. 바카라 게임 웹사이트What does that mean? And we just don바카라 게임 웹사이트t know.바카라 게임 웹사이트
A 바카라 게임 웹사이트Catch-22바카라 게임 웹사이트
The drugs바카라 게임 웹사이트 makers are also following the 바카라 게임 웹사이트Ozempic babies바카라 게임 웹사이트 phenomenon. Eli Lilly바카라 게임 웹사이트s chief of research, Dr. Daniel Skovronsky, says the company has heard these kinds of stories from patients.
바카라 게임 웹사이트One question we바카라 게임 웹사이트re asking is: is it possible that as we reduce fat, we improve fertility, decrease PCOS and other barriers to fertility?바카라 게임 웹사이트 Skovronsky said.
바카라 게임 웹사이트It바카라 게임 웹사이트s kind of like heart failure or sleep apnea,바카라 게임 웹사이트 he said, referring to conditions for which GLP-1 drugs have recently shown positive results. 바카라 게임 웹사이트Just another potential benefit of weight loss from this class of medications that we haven바카라 게임 웹사이트t tested yet.바카라 게임 웹사이트
He also underlined how tricky it is to run studies around fertility of medicines whose safety in pregnancy is unknown; Cree referred to a requirement for birth control in studies of GLP-1 drugs as a 바카라 게임 웹사이트Catch-22바카라 게임 웹사이트 for fertility indications.
바카라 게임 웹사이트Right now, unfortunately, it바카라 게임 웹사이트s really hard to study the effects of these drugs on fertility, because that implies exposing women to a drug with a high risk that they바카라 게임 웹사이트ll have a pregnancy during exposure to the drug and the risks to the baby haven바카라 게임 웹사이트t been fully analyzed yet,바카라 게임 웹사이트 Skovronsky said.
Bentley, who got pregnant while taking Mounjaro, said she stopped taking the medicine as soon as she found out she was pregnant. But she said she continued to worry about the effect of the drug on her baby.
바카라 게임 웹사이트I worried up until the day I had her,바카라 게임 웹사이트 she said.
Her daughter, Ivy, was born healthy on her due date, weighing 7 pounds and 7 ounces. Bentley started taking Mounjaro again six weeks after Ivy was born.
Catera Bentley via CNN 온라인 바카라 게임ource
Catera Bentley said she worried about her baby’s health up until her daughter, Ivy, was born.
