Wegovy shown to reduce risk of heart attack, stroke in major cardiovascular trial
The weight loss drug Wegovy was shown to reduce the risk of heart attack, stroke or heart-related death by 20% in what바카라 게임 웹사이트s being called a landmark clinical trial in people with cardiovascular disease, the first to show a weight loss drug alone can have such protective effects.
studied Wegovy against placebo in addition to standard of care for prevention of major adverse cardiac events in 17,604 adults with heart disease and obesity or who were overweight, but who didn바카라 게임 웹사이트t have diabetes. It called the five-year trial 바카라 게임 웹사이트Select.바카라 게임 웹사이트
The finding of a 20% reduction in heart risk is higher than many experts had anticipated. A similar trial for the type 2 diabetes drug Ozempic, which uses the same ingredient, semaglutide, previously showed it could reduce cardiovascular risk by 26% 바카라 게임 웹사이트 but no trial had yet shown a risk reduction in people without diabetes.
바카라 게임 웹사이트Historically, trials of drugs for weight loss have been very unsuccessful, and some of them have shown harm,바카라 게임 웹사이트 Cleveland Clinic바카라 게임 웹사이트s Dr. Steven Nissen told CNN Tuesday. 바카라 게임 웹사이트This is an important trial and I think the term 바카라 게임 웹사이트landmark바카라 게임 웹사이트 is appropriate.바카라 게임 웹사이트
Nissen emphasized, though, that these are just topline results shared by news release. He emphasized that it바카라 게임 웹사이트s crucial to see full results presented at a scientific conference and published in a peer-reviewed journal. Specifically, he noted the news release didn바카라 게임 웹사이트t discuss adverse events or the specific effects on each measure of heart risk: cardiovascular death, heart attack and stroke.
바카라 게임 웹사이트That doesn바카라 게임 웹사이트t mean it바카라 게임 웹사이트s not a good result,바카라 게임 웹사이트 he said, 바카라 게임 웹사이트it just means we don바카라 게임 웹사이트t know.바카라 게임 웹사이트
Novo Nordisk바카라 게임 웹사이트s executive vice president for development, Martin Holst Lange, said in the news release that the trial 바카라 게임 웹사이트has demonstrated that semaglutide 2.4mg has the potential to change how obesity is regarded and treated.바카라 게임 웹사이트
Video below: Is injecting Ozempic, Wegovy, Mounjaro to lose weight safe?
The findings, once peer-reviewed and published in a medical journal, may encourage more doctors to prescribe the wildly popular weight loss drug, but could also potentially help improve insurance coverage, physicians told CNN.
바카라 게임 웹사이트If the Select study is positive, it will add to the growing body of evidence that weight loss is not just cosmetic and will encourage insurers to pay for medications that reduce weight,바카라 게임 웹사이트 Dr. Willa Hsueh, director of the Diabetes and Metabolism Research Center at Wexner Medical Center at The Ohio State University, told CNN before the results were released.
Wegovy $1,349 a month before insurance, and coverage has been difficult for many patients in the U.S.
바카라 게임 웹사이트For weight loss right now, I would call it poor,바카라 게임 웹사이트 said Dr. Jena Shaw Tronieri, director of Clinical Services at the Center for Weight and Eating Disorders at the Perelman School of Medicine at the University of Pennsylvania, in an interview before the trial results. 바카라 게임 웹사이트We do see a lot of patients struggling to access these medications.바카라 게임 웹사이트
Novo Nordisk said Wegovy appeared to have a 바카라 게임 웹사이트safe and well-tolerated profile바카라 게임 웹사이트 in the study, in line with what it has seen in previous trials.
The company said it will submit applications with regulators to add the cardiovascular benefits to the drug바카라 게임 웹사이트s prescribing information, and said it will present detailed results from the trial at a scientific conference later this year.
Those steps are key to improving reimbursement, Nissen said.
바카라 게임 웹사이트I can tell you that the pharmacy benefit managers who now rule the world will not generally pay for something based on a press release,바카라 게임 웹사이트 he said.
Nissen is leading a similar trial for tirzepatide, a drug made by Eli Lilly and sold for type 2 diabetes as Mounjaro. It바카라 게임 웹사이트s awaiting U.S. Food and Drug Administration approval for weight loss as well. In an interview before the results of the Wegovy trial, he said expectations may have been for a benefit of about 15%.
바카라 게임 웹사이트I think for a drug that requires patients to inject weekly, that바카라 게임 웹사이트s relatively expensive, a meaningful result 바카라 게임 웹사이트 is a 15% relative risk reduction,바카라 게임 웹사이트 Nissen said. But he noted he바카라 게임 웹사이트d be disappointed with that level. 바카라 게임 웹사이트Something more Iike 20% for a biological is a more reasonable one.바카라 게임 웹사이트
